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KMID : 0854720070270020111
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 2 p.111 ~ p.117
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A Comparative Study between External Resistive Loads to Breathing and Induced Bronchoconstriction on Dyspnea Perception in Asthma
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Choi In-Seon
Jeong Seong-Hoon
Cheong Dae-Ho
Lee Woo-Jin
Han Eui-Ryoung
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Abstract
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Background: Since blunted perception of dyspnea may predispose to fatal asthma attacks, dyspnea perception should be measured in severe asthma. Few studies have comparedthe testing methods.
Objective: To investigate whether the degree of dyspnea perception depends on the testing method in asthma.
Method: The Borg scale-based dyspnea perception scores during breathing through an inspiratory muscle trainer, and during bronchoprovocation tests using histamine or methacholine were measured in asthma patients and normal volunteers. The relationships between Borg scores and atopy markers were determined.
Result: The ΔBorg scores induced by the external resistive loads were significantly lower in subjects with moderateto- severe airway hyperresponsiveness (AHR) to histamine than in those with negative AHR (P=0.021). Among the patients with AHR to both histamine and methacholine (n=19), the ΔBorg scores/Δlung function ratio induced by histamine was significantly higher than that by methacholine (15.6±2.3 vs. 9.5±2.1, P＜0.05). The load-induced ΔBorg scores were significantly related to serum total IgE levels(r=0.541, P＜0.05).
Conclusion: Dyspnea perception depends on AHR severity. Histamine induces more severe dyspnea than methacholine, and allergy may affect dyspnea perception. Dyspnea perception vary according to the testing methods. (Korean J Asthma Allergy Clin Immunol 2007;27:111-117)
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KEYWORD
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Asthma, Dyspnea, Perception, Load, Responsiveness
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